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Pharmacology

Severe irritability in children and teens: A new understanding

Kids with disruptive mood dysregulation disorder have explosive outbursts well past toddler age. Scientists are trying to work out the causes and what treatments help.

Studies of migraine’s many triggers offer paths to new therapies

One class of drugs has already found success in treating the painful, disorienting and common attacks. Excitement is building about a slew of additional drug targets.

Why a diabetes drug fell short of anticancer hopes

Population and animal studies suggested it could treat cancer, but the clinical trials were a bust. Here’s what happened and what potential may remain.

Targeting the racial disparity in kidney disease

Some people of West African descent face a higher risk of renal failure. New drugs based on gene research may help right the ship — if they can reach everyone who needs them.

What if a virus could reverse antibiotic resistance?

In promising experiments, phage therapy forces bacteria into a no-win dilemma that lowers their defenses against drugs they’d evolved to withstand

The tussle over cigarette warning labels, and the hazy future of vaping

Regulatory hurdles, industry objections and legal fights have gone on for decades over traditional tobacco. What’s in store for the next generation of smoking?

Radioactive drugs strike cancer with precision

The tumor-seeking radiopharmaceuticals are charting a new course in oncology, with promise for targeted treatments with fewer side effects

To pee or not to pee? That is a question for the bladder — and the brain

How do we sense the need to urinate? The basic urge is surprisingly complex and can go awry as we age.

Fit for a dog? The latest science on CBD for pets

Though studies are still mixed, and products often inconsistent, many scientists have hope that cannabidiol can help canines and other furry patients suffering from arthritis, allergies and anxiety

What’s next in the Ozempic era?

Diabetes, weight loss and now heart health: A new family of drugs is changing the way scientists are thinking about obesity — and more uses are on the horizon

Psychedelic drugs and the law: What’s next?

The push to legalize magic mushrooms, MDMA, LSD and other hallucinogens is likely to heighten tensions between state and federal law, drug law expert Robert Mikos says

All about cholesterol

The latest science on how blood levels of HDL, LDL and more relate to cardiovascular health

We urgently need data for equitable personalized medicine

OPINION: A massive bias in medical studies toward men of European origin means that genetic variants in understudied populations don’t get the focus they deserve

The remaining frontiers in fighting hepatitis C

A scientist whose work was key to identifying, studying and finding treatments for this life-threatening virus discusses the scientific journey and challenges that persist

Medications for opioid use disorder — MOUD — and adolescents

Treatment with drugs such as buprenorphine, methadone and naltrexone is deemed the gold standard for youth with opioid addictions. Why isn’t it used more often?

How the placebo effect went mainstream

PODCAST: Sloppy by today’s standards, and maybe even back when it was published in 1955, Henry Beecher’s paper paved the way for sounder drug trials and pushed scientists to better understand how we process pain (Season 3, Episode 3)

After Covid-19, can mRNA vaccines help with cancer as well?

The pandemic put the technology, long in development, to the test. Here’s a look at the status of its application to cancer and when it might reach patients.

Hope for haploinsufficiency diseases

Genetic conditions like Dravet syndrome, which causes severe childhood epilepsy, are hard to tackle with traditional gene therapy. New approaches in the works include using antisense therapy to boost mRNA splicing.

Scientific highs and lows of cannabinoids

Hundreds of these cannabis-related chemicals now exist, both natural and synthetic, inspiring researchers in search of medical breakthroughs — and fueling a dangerous trend in recreational use

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